Pyrithione reduces the intracellular level of oxandrolonecontributes to depolarization of cell membranes, causing the death of fungi and bacteria. Antifungal activity is particularly pronounced in effect on and Pityrosporum ovale Pityrosporum orbiculare, causing inflammation and excessive flaking dandruff, seborrheic dermatitis, psoriasis and other skin diseases. An anti-inflammatory mechanism of action has not been studied. When applied topically pyrithione  deposited in the epidermis and superficial dermis. Systemic absorption is insignificant. The drug is found in trace amounts in the blood.

Indications

 

  • psoriasis,
  • atopic dermatitis (eczema, atopic dermatitis)
  • seborrheic dermatitisContraindications:
    Hypersensitivity, oxandrolone children up to 1 year.

    Dosing and Administration
    The drug is intended for external use only.
    Apply in adults and children from 1 year.
    Before use, shake the bottle. Spray the drug to the affected area of the skin from a distance of 15 cm 2-3 times a day to achieve a clinical effect. For the treatment of drug scalp attached additional nozzle.Use of the drug, it is desirable to continue for one week after disappearance of symptoms.
    The duration of treatment with:

  • psoriasis 1-1.5 months, repeated courses – with the appearance of acute symptoms;
  • atopic dermatitis 3-4 weeks;
  • seborrheic dermatitis 2 weeks.Side effects:
    The drug is generally well oxandrolone tolerated. Rarely – allergic reactions. In the first days of treatment possible short-term burning sensation at the site of application of the drug, which, as a rule, does not require its cancellation.

    Overdose
    So far, cases of overdose of zinc pyrithione have been reported.

    Interaction with other drugs
    clinically significant interaction of zinc pyrithione with other drugs have been identified.

    Cautions
    When spraying, keep the bottle upright.

    Product form
    aerosol for external use 0.2%.
    At 35 g or 58 g in aluminum aerosol cans fitted with a continuous valve and protective cap.
    The cylinder with the spray oxandrolone for topical use, additional nozzle and instructions for use placed in a pile of cardboard.