Tsipraleks is an antidepressant, a selective serotonin reuptake inhibitor (SSRI). Inhibition of reuptake of serotonin leads to increasing the concentration of the neurotransmitter in the synaptic cleft, amplifies and prolong its effect on post-synaptic receptor sites.
Escitalopram has no or has a very weak ability to bind to a number of receptors including: serotonin buy anavar receptors, dopamine receptors, receptors , muscarinic cholinergic, benzodiazepine, and opioid receptors.
Pharmacokinetics. The absorption is independent of food intake. The bioavailability of escitalopram is approximately 80%. The mean time to maximum plasma concentration buy anavar 4 hours after repeated use. The apparent volume of distribution after oral administration is from 12 to 26 l / kg. The binding of escitalopram and its main metabolites in the plasma proteins below 80%. Escitalopram is metabolised in the liver to the demethylated and didemetilirovannogo metabolites. Both are pharmacologically active. Main ingredient and its metabolites in the form of partially allocated glucuronides.
After repeated use and the average concentration didemetil- demethyl metabolite is typically 28-31% and less than 5%, respectively, the concentration of escitalopram. Biotransformation of escitalopram in desmethyl metabolite occurs mainly through the cytochrome buy anavar. Perhaps some part of isoenzymes In persons with a weak activity escitalopram concentration twice higher than in the case of high activity of the isozyme.Significant changes in the concentration of the drug in cases of weak activity isoenzyme were found.
Theis reusable after about 30 hours. Clearance when administered orally buy anavar is about 0.6 L / min. In the main metabolites of escitalopram half-life is longer. Escitalopram and major metabolites are excreted by the liver (metabolic pathway) and kidneys. Most metabolites excreted as urine.
Kinetics of escitalopram is linear. The equilibrium concentration (the C ss ) is achieved after about 1 week. The mean is achieved at a daily dose of 10 mg.
In the elderly (over 65 years) Escitalopram appears slower than in younger patients. The amount of substance present in the systemic circulation, calculated using farmakokineticheckogo indicator “area under the curve» in the elderly by 50% more than in young healthy volunteers.
Depressive episodes of any severity.
Panic disorder with / without agoraphobia.
Social anxiety disorder (social phobia).
Generalized anxiety disorder.
Hypersensitivity to the drug or its components,
Children and Youth age (up to 18 years),
simultaneous reception with monoamine oxidase inhibitors .
DOSAGE AND ADMINISTRATION
Tsipraleks administered orally once a day, regardless buy anavar of the meal. Depressive episodes usually given 10 mg once daily. Depending on the individual patient’s response the dose may be increased to a maximum of -. 20 mg / day Antidepressant effect usually develops within 2-4 weeks after starting treatment. After the disappearance of symptoms of depression, as a minimum, even 6 months therapy is necessary to continue to secure the effect obtained.
hydrolyzed collagen protein bodybuilding side bends with dumbells supplement diet for bodybuilding