Tsipramil has no or very poor ability to bind to a number of receptors, including histamine, muscarinic and adrenergic receptors. This is largely due to the lack of cardiotoxicity tsipramil and side effects in the form of orthostatic hypotension, sedation, dry mouth. Tsipramil only to a very small extent it inhibits cytochrome R450IID6, and therefore does not interact with drugs metabolized by this enzyme.
The antidepressant effect usually develops anavar only cycle after 2-4 weeks of treatment. Tsipramil no influence on the conductive system of the heart and blood pressure, hematologic parameters, liver and kidney function, does not cause weight gain.
Bioavailability when administered citalopram is about 80%. Maximum plasma concentration is achieved 2-4 hours after administration.Protein binding – below 80%. Metabolism is accomplished by demethylation, deamination and oxidation. Unmodified citalopram base compound is in the blood plasma; its kinetics is linear. Constant plasma concentration is set after 1-2 weeks of treatment. The half-life of 1.5 days. Withdrawal is carried out with the urine and feces.
Treatment of depression of different etiology and structure in adults. Treatment of panic disorder with / without agoraphobia. Treatment of obsessive-compulsive disorder anavar only cycle.
Cipramil is contraindicated in case of hypersensitivity to citalopram or any of the excipients.
The drug should not be used in combination with monoamine oxidase inhibitors including selegiline and for 14 days after the termination of their admission. Treatment of anavar only cycle inhibitors can be started no earlier than 7 days after.
Do not assign tsipramil pregnant and lactating women, if the potential clinical benefit prevails over theoretical risk, since safety of the drug during pregnancy and lactation has not been established in humans.
DOSAGE AND ADMINISTRATION
tsipramil administered once a day. The drug can be used at any time of the day regardless of the meal. Depression: depression therapy begins with receiving per day. Depending on the individual response of the patient and the severity of depression, the dose may be increased to a maximum – 60 mg per day. Panic Disorder: during the first weeks of treatment is recommended dose anavar only cycle of 10 mg per day tsipramil, then the dose increased to 20 mg per day. The daily dose, depending on the individual patient’s response, can be further increased. . The maximum dose – 60 mg / day Obsessive-compulsive disorder: an initial is 20 mg per day. The dose may be increased if necessary. The maximum dose -. 60 mg per day . Elderly anavar only cycle patients (over 65 years) The recommended daily dose for the elderly is 20 mg. Depending on the individual response and the severity of depression, the dose may be increased to a maximum of -. 40 mg per day In liver failure the drug should be limited to the minimum recommended dose. The maximum dose -. 30 mg per day At low and moderate renal insufficiency correction dose is not required.